The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation

Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number resources, high-level availability and possibility cultivation have provided high prospects plant raw materials development new herbal medicines. Primula denticulate Smith. is one most interesting medicinal source modern medicine pharmacy with wide spectrum pharmacotherapeutic action, that mainly only traditional medicine. Thus, nowadays effective based on tablet dosage form topical task pharmacy.
 The aim work. To study influence excipients pharmaco­technological parameters tablets Smith, obtained by wet granulation method to substantiate choosing best mathematical planning experiment.
 Materials Methods. It was a self-prepared dense extract excipients, which complied requirements State Pharmacopoeia Ukraine terms pharmaco-technological quality parameters, for developing tablets. hyper Greek-Latin square 4x4 four qualitative factors.
 Results Discussion. In course experiment, it determined dependence (friability, resistance crushing disintegration tablets) type excipients. selected optimal further research quality.
 Conclusions. 
 According it’s chosen obtaining Considering investigated properties composition determined: Avicel PH - 105 MCC 101, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate Prosolv 90.